›› 2012, Vol. 24 ›› Issue (1): 56-59.doi: 10.3969/j.issn.1004-616x.2012.01.013

• 肿瘤防治 • Previous Articles     Next Articles

mRNA expression of oncogenes in patients with allergic dermatitis induced by trichloroethylene

XU Xin-yun，LIU Yue-feng，YI Juan，ZHOU Li，HUANG Xin-feng，MAO Ji-yan，MAO Kan-lang   

  1. 1. Shenzhen Center for Disease Control and Prevention, Shenzhen 518055; 2. Shenzhen Hospital for Occupational Disease Prevention and Treatment, Shenzhen 518001, Guangdong, China
  • Received:2011-05-19 Revised:2011-09-16 Online:2012-01-30 Published:2012-01-30
  • Contact: XU Xin-yun

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Abstract: OBJECTIVE: To study mRNA expression of oncogenes (c-fos，c-myc，K-ras，p53) in peripheral blood of patients allergic to trichloroethylene (TCE). METHODS：Peripheral blood samples were collected from healthy workers (control group) and allergic patients (case group). Real-time quantitative PCR was applied to detect mRNA expression of oncogenes c-fos，c-myc，K-ras，p53. RESULTS：The level of c-fos mRNA expression increased by 352% in TCE patients when compared with control (P<0.01)，c-myc increased by 41%，K-ras by 136% and p53 increased by 64%. mRNA expression levels of these oncogenes showed significant differences between case and control groups (P<0.01 or P<0.05). CONCLUSION：Trichloroethylene could induce oncogene expression in patients with allergic dermatitis， indicating that TCE might be potentially carcinogenic.

Key words: trichloroethylene, peripheral blood, oncogenes, real-time PCR, carcinogenicity